马春华

马春华



个人简介:马春华,男,博士,讲师,中国化学会会员。E-mail: 2016007@htu.edu.cn

教育经历:
2004.09-2008.06 
山东大学药学院,药学专业,理学学士;
2008.09-2013.12 
山东大学药学院,药物化学专业,理学博士;

工作经历:

2013.12-2015.12,复旦大学药学院,药物化学专业,博士后;

2016.03-至今,河南师范大学化学化工学院讲师。

研究领域与兴趣:

1、小分子抗肿瘤药物的设计合成

2、基于靶点的先导化合物的设计和结构优化

近年来主持的主要科研项目:

1、国家自然科学基金青年基金:基于腺嘌呤替代物的双底物SAHH抑制剂的设计、合成及活性研究,项目批准号:82003585, 2021.01-2023. 12, 24.00万元

2河南省自然科学基金:小分子神经生长因子模拟物的设计、合成及作用机制研究,项目编号:162300410182, 2017.1-2018.12, 10万元

3、河南省高等学校重点科研项目基础研究计划:小分子NGF模拟物的设计、合成及应用研究,项目编号:17A350008, 2017.1-2018.123万元

4、高端外国专家项目:I类新药布鲁顿酪氨酸激酶抑制剂BTK inhibitor HB040的研究与开发,项目编号GDW20186300346, 30万元

5、企业横向:新型BTK抑制剂的研究与开发,合同编号XH201905950万元

代表性论文:

19)Chunhua Ma, Xiaofeng Li, Xiya Chen, Xing He, Shu-Ting Zhang,* Yu-Qin Jiang,* and Bing Yu*, Photocatalytic umpolung strategy for the synthesis of α-amino phosphine oxides and deuterated derivatives. Organic Letters, 2023, 25, 44, 8016-8021.

18)Chunhua Ma, Yu Tian,  Junyan Wang, Xing He, Yuqin Jiang*, Bing Yu*, Visible-Light-Driven Transition-Metal-Free Site-Selective Access to Isonicotinamides.Organic Letters, 2022, 24, 8265-8270.

17)Jin Wang, Qingyuan Song, Xing He, Chunhua Ma,* Yuqin Jiang,* and Jing Fan,* Visible light-promoted, photocatalyst-free decarboxylative alkylation of 2H-indazoles via electron donor-acceptor complex activation. New Journal of Chemistry2022, 46, 16436-16439.

16)Chunhua Ma, Hui Meng, Jing Li, Xianguang Yang, Yuqin Jiang*, Bing Yu*, Photocatalytic Transition-Metal-Free Direct 3-Acetalation of Quinoxaline-2(1H)-ones, Chinese Journal of Chemistry, 2022, 40, 2655-2662.

15)Chunhua Ma, Yue Wang, Guang Chen, Jingyi Li, Yuqin Jiang, Xinying Zhang,* and Xuesen Fan*. Divergent construction of 3-(indol-2-yl)succinimide/maleimide and fused benzodiazepine skeletons from 2-(1H-indol-1-yl)anilines and maleimides. Organic Chemistry Frontiers, 2022, 9, 4663-4669.

14)Chunhua Ma, Hui Meng, Xing He, Yuqin Jiang*, Bing Yu*, Visible-Light-Promoted Transition-Metal-Free Construction of 3-Perfluoroalkylated Thioflavones, Frontiers in Chemistry, 2022, 10, 953978.

13) Chunhua Ma, Lu Zhao, Xing He, Yuqin Jiang,* and Bing Yu*, Visible-light-induced direct 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles in water, Organic Chemistry Frontiers, 2022, 9, 1445-1450.

12) Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors  Journal of Medicinal Chemistry, 202164, 1624216270.

11Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,* Yuqin Jiang,* and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis.  Chinese Journal of Catalysis, 202243, 571-583.

10Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry2021, 225, 113724.

9)Chunhua MaZhiwen Feng, Jing Li, Dandan Zhang, Wei Li,Yuqin Jiang*and Bing Yu*. Photocatalytic Transition-Metal-Free Direct 3-Alkylation of 2-Aryl-2H-Indazoles in Dimethyl Carbonate, Organic Chemistry Frontiers2021, 8, 3286-3291.

8)Yuqin JiangJing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction, Advanced Synthesis & Catalysis2020,  362(13), 2609-2614.

7)Zhiwen Feng, Jing Li, Yuqin Jiang, Yu Tian, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*, Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones, New Journal of Chemistry, 2020, 44, 14786-14790.

6) Jiaxuan Shen,* Nannan Li, Yanjiang Yu, and Chunhua Ma*. Visible-Light-Induced Oxidation/[3 + 2] Cycloaddition/Oxidative Aromatization to Construct Benzo[a]carbazoles from 1,2,3,4-Tetrahydronaphthalene and Arylhydrazine HydrochloridesOrganic Letter 2019, 21(17), 7179-7183.

5) Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH). Tetrahedron 2018, 74 (27), 3602-3607.

4) Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water. Organic & Biomolecular Chemistry 2017, 15 (46), 9889-9894.

3) Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation. European Journal of Medicinal Chemistry 2016, 108, 21-27.

2) Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry Letters2013, 23 (17), 4948-4952.

1) Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry 2013, 21 (7), 1621-1627.





获得荣誉与奖励:

河南师范大学优秀教师









Individual profileChunhua MaMalePh DlecturerMembership of China Chemical Society.E-mail: 2016007@htu.edu.cn

Education experience
2004.09-2008.06 School of pharmaceutical sciences Shandong University, Pharmacology, Bachelor of Science;
2008.09-2013.12 School of pharmaceutical sciences Shandong University,
Medicinal chemistry, Doctor of Medicine.

Work experience

2013.12-2015.12, School of Pharmacy Fudan University, Medicinal chemistry, Post doctor;

2016.03-until now, School of Chemistry and Chemical Engineering, Henan Normal University, Lecturer.

Research Interest

1The design and synthesis of small molecular compounds with antitumor activity

2Target-based design and structure optimization of lead compounds

近年来主持的主要科研项目:
1
Henan Natural Science FoundationThe design, synthesis and mechanism of small molecular never growth factor mimics, Project number162300410182, 2017.1-2018.12, 0.1Million

2Basic Research Plan of Key Scientific Research Projects in Henan Higher Education InstitutionsThe design, synthesis and application of small molecular never growth factor mimics, Project number17A350008, 2017.1-2018.120.03 Million

3High-end Foreign Expert ProjectResearch and Development of Bruton Tyrosine Kinase Inhibitor (BTK inhibitor HB040), Project numberGDW201863003463 Million

代表性论文:


12) Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors  Journal of Medicinal Chemistry, 2021,64, 1624216270..

11Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,* Yuqin Jiang,* and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis.  Chinese Journal of Catalysis, 2021DOI: 10.1016/S1872-2067(21)63917-7

10Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry2021225, 113724.

9)Chunhua MaZhiwen Feng, Jing Li, Dandan Zhang, Wei Li,Yuqin Jiang*and Bing Yu*. Photocatalytic Transition-Metal-Free Direct 3-Alkylation of 2-Aryl-2H-Indazoles in Dimethyl Carbonate, Organic Chemistry Frontiers2021,  DOI: 10.1039/D1QO00064K.

8)Yuqin JiangJing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction, Advanced Synthesis & Catalysis2020,  362(13), 2609-2614.

7)Zhiwen Feng, Jing Li, Yuqin Jiang, Yu Tian, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*, Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones, New Journal of Chemistry, 2020, 44, 14786-14790.

6) Jiaxuan Shen,* Nannan Li, Yanjiang Yu, and Chunhua Ma*. Visible-Light-Induced Oxidation/[3 + 2] Cycloaddition/Oxidative Aromatization to Construct Benzo[a]carbazoles from 1,2,3,4-Tetrahydronaphthalene and Arylhydrazine HydrochloridesOrganic Letter 2019, 21(17), 7179-7183.

5) Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH). Tetrahedron 2018, 74 (27), 3602-3607.

4) Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water. Organic & Biomolecular Chemistry 2017, 15 (46), 9889-9894.

3) Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation. European Journal of Medicinal Chemistry 2016, 108, 21-27.

2) Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry Letters 2013, 23 (17), 4948-4952.

1) Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry 2013, 21 (7), 1621-1627.



获得荣誉与奖励:

Excellent Teachers of Henan Normal University




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