朱博

时间:2020-05-22浏览:5778设置


朱博博士副教授硕士生导师

入选博士后创新人才支持计划(2017年)

河南省优秀青年科学基金获得者(2021年入选)

E-mail:zbtiantang@126.comzhubo2019@htu.edu.cn



教育经历:

20059月—20097月,河南大学,药学院,理学学士学位

20099月—20127月,河南大学,药学院,医学硕士学位,导师:江智勇教授、严琳教授

20139月—20167月,河南大学,化学化工学院,理学博士学位,导师:江智勇教授


工作经历:

20128月—20138月,漯河医学高等专科学校        辅导员

20174月—20196月,河南师范大学,化学化工学院,师资博士后,合作导师:常俊标教授

20196月—至今,河南师范大学,化学化工学院,副教授


研究领域与兴趣:

1. 不对称催化合成

2. 抗肿瘤、抗抑郁药物合成


近年来主持的主要科研项目:

河南省自然科学基金-优青,2021年,在研,主持

国家自然科学基金(81903465):手性含氟东莨菪碱类似物的设计、合成及其抗抑郁活性研究,主持。

博士后创新人才支持计划(BX201700071药物分子中手性仲醇构建新手段,主持。

博士后面上基金(2017M622348构建γ-官能团化非相邻手性仲醇的不对称质子化反应,主持。


代表性论文:

20)Li, L.; Zhu, B.*; Fan, H.; Jiang, Z.; Chang, J.* Direct organocatalytic asymmetric Michael reaction of fluorine hemiaminal-type nucleophile to 4-nitro-5-styrylisoxazoles. Organic Chemistry Frontiers 2020, 7, 1343–1348

(19)Xu, X.; He, Y.; Zhou, J.; Li, X.; Zhu, B.*; Chang, J.* Organocatalytic Asymmetric Michael Addition of Pyrazol-5-ones to β‑Trifluoromethyl-α,β-unsaturated Ketones: Stereocontrolled Construction of Vicinal Quaternary and Tertiary Stereocenters. J. Org.   Chem.2020, 85, 574−584

18)Lu, B.; Xin, S.; Zhu, B.*; Chang, J.* Enantioselective Conjugate Addition–Protonation of 5H-Oxazol-4-ones and 5-Methylene 1,3-oxazolidine-2,4-diones: 2,2'-Biphenol-Induced Diastereoselectivity Switch. Chin. J. Chem. 2019, 37, 689-694. (invited)

17)Zhu, B.; Lu, B.; Zhang, H.; Xu, X.; Jiang, Z.*; Chang, J.* Phase-Transfer-Catalyzed, Enantioselective Vinylogous Conjugate Addition−Cyclization of Olefinic Azlactones To Access Multifunctionalized Chiral Cyclohexenones. Org. Lett. 2019, 21,3271-3275.

16)Chai, G.; Zhu, B.; Chang, J.* Synthesis and Application of Substituted 1,16-Dihydroxytetraphenylenes in Catalytic symmetric Allylboration of Ketones. J. Org. Chem. 2019, 84, 120–127.

15)Xia, X.; Zhu, Q.; Wang, J.; Chen, J.; Cao, W.; Zhu, B.*; Wu, X.* Direct Asymmetric Vinylogous Mannich Addition of 3,5-Disubstituted-4-nitroisoxazoles to Isatin-Derived Imines Catalyzed by a Bifunctional Phase-Transfer-Catalyst. J. Org. Chem. 2018, 83, 14617–14625.

14)Zhu, B.; Li, F.; Lu, B.; Chang, J.*; Jiang, Z.* Organocatalytic Enantioselective Vinylogous Aldol Reaction of 5-Alkyl-4-Nitroisoxazoles to Paraformaldehyde. J. Org. Chem. 2018, 83, 11350–11358.

13)Zhu, B.; Lee, R.; Yin, Y.; Li, F.; Coote, M.*; Jiang, Z.* Enantioselective Vinylogous Amination of 5-Alkyl-4-nitroisoxazoles with a Dipeptide-Based Guanidinium Phase-Transfer Catalyst. Org. Lett. 2018, 20, 429−432.

12)Li, S.; Zhu, B.(共一); Lee, R.; Qiao, B.; Jiang, Z.* Visible light-induced selective aerobic oxidative transposition of vinyl halides using a tetrahalogenoferrate(III) complex catalyst. Organic Chemistry Frontiers 2018, 5, 380−385.

11)Zhu, B.; Qiu, S.; Li, J.; Coote, M. L.; Lee, R.; Jiang, Z.* Asymmetric [4+2] annulation of 5H-thiazol-4-ones with a chiral dipeptide-based Brønsted base catalyst. Chem. Sci. 2016, 7, 6060–6067.

10)Zhu, B.; Lee, R.; Li, J.; Ye, X.; Hong, S.-N.; Qiu, S.; Coote, M. L.; Jiang, Z.* Chemoselective Switch in Asymmetric Organocatalysis of 5H-oxazol-4-ones and N-Itaconimides towards Tandem Conjugate Addition−Protonation or [4+2] Cycloaddition. Angew. Chem. Int. Ed. 2016, 55, 1299−1303.

9)Zhu, B.; Zhang, W.; Lee, R.; Han, Z.; Yang, W.; Tan, D.; Huang, K.-W.; Jiang, Z.* Direct Asymmetric Vinylogous Aldol Reaction of Allyl Ketones with Isatins: Divergent Synthesis of 3-Hydroxy-2-Oxindole Derivatives. Angew. Chem. Int. Ed. 2013, 52, 6666–6670 (Selected as the inside back cover picture of Angewandte Chemie) (Highlighted by Synfacts 2013, 9, 0784–0784; Contributors: Benjamin List, Mattia Riccardo Monaco).

8)Zhu, B.; Yan, L.; Pan, Y.; Lee, R.; Liu, H.; Han, Z.; Huang, K.-W.; Tan. C.-H.; Jiang, Z. Lewis Base Catalyzed Enantioselective Allylic Hydroxylation of Morita-Baylis-Hillman Carbonates with Water. J. Org. Chem. 2011, 76, 68946900.

14)Zhao, X.; Zhu, B.; Jiang, Z.* Acyclic Amino Acid-Based Bifunctional Chiral Tertiary Amines, Quaternary Ammoniums and Iminophosphoranes as Organocatalysts. Synlett 2015, 26, 2216−2230. (Invited Account).

7)Tong, G.; Zhu, B.; Lee, R.; Yang, W.; Tan, D.; Yang, C.; Han, Z.; Yan, L.; Huang, K.-W.; Jiang, Z.* Highly Enantio- and Diastereoselective Allylic Alkylation of Morita-Baylis-Hillman Carbonates with Allyl Ketones. J. Org. Chem. 2013, 78, 5067–5072.

6)Qiu, S.; Lee, R.; Zhu, B.; Coote, M. L.; Zhao, X.; Jiang, Z.* Highly Enantio- and Diastereoselective [4 + 2] Cycloaddition of 5H oxazol-4-ones with N Maleimides. J. Org. Chem. 2016, 81, 8061−8069.

5)Yan, L.; Han, Z.; Zhu, B.; Yang, C.; Tan, C.-H.; Jiang, Z.* Asymmetric Alylic Alkylation of Morita-Baylis-Hillman Carbonates with α-Fluoro-β-Keto Esters. Beilstein J. Org. Chem. 2013, 9, 1853–1857.

4)Li, J.; Qiu, S.; Ye, X.; Zhu, B.; Liu, H,; Jiang, Z.* Dipeptide-Based Chiral Tertiary Amine-Catalyzed Asymmetric Conjugate Addition Reactions of 5H-Thiazol/Oxazol-4-Ones. J. Org. Chem. 2016, 81, 11916−11923.

3)Jiang, Z.; Bai, X.; Chen, W.; Zhang, G.; Zhu, B.; Jiang, Z.* Organocatalytic Enantioselective Vinylogous Aldol Reaction of Allyl Ketones to Activated Acyclic Ketones. Org. Lett. 2016, 18, 260−263.

2)Yang, C.; Chen, W.; Yang, W.; Zhu, B.; Yan, L.; Tan, C.-H.; Jiang, Z.* Bicyclic-Guanidine-Catalyzed Asymmetric Michael Addition of 3-Substituted Oxindoles to 2-Cyclopentenone. Chem. Asian J. 2013, 8, 2960−2964.

1)Yang, W.; Wei, X.; Pan, Y.; Lee, R.; Zhu, B.; Liu, H.; Yan, L.; Huang, K.-W.; Jiang, Z.;* Tan, C.-H. Highly Enantio- and Diastereoselective Synthesis of β-Methyl-γ- Monofluoromethyl-Substituted Alcohols. Chem. Eur. J. 2011, 17, 80668070. (VIP paper)






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